XS1
Work with XS1 Biosciences

XS1 Biosciences

From sequence to function.

XS1 Biosciences builds AI for biological and genetic research: genomic and protein language models, single-cell models and research agents that help scientists reason from a sequence to what it does.

Work with XS1 BiosciencesResponsible science
  • Genomic models
  • Variant effects
  • Genome editing
  • Protein design
  • Single-cell models
  • Research agents

01What we build

Models that read DNA, RNA and protein.

Biology is written in sequences. XS1 Biosciences trains and adapts models that learn from them at each layer, and agents that put those models to work in research.

Illustrative

Reading a gene, codon by codon

Eight codons → MAKWELYS

Illustrative: the DNA codons ATG GCT AAG TGG GAA CTG TAC AGC are transcribed into mRNA and translated into the amino acids Met, Ala, Lys, Trp, Glu, Leu, Tyr, Ser.

Across all threeResearch agents read the literature and run analysis at every layer.
  1. 01Genomic language modelsModels trained on DNA and RNA from many genomes, which learn the patterns that control how genes are used.
  2. 02Variant-effect researchEstimating whether a change in sequence is likely to change what a gene does, as a signal for which variants to study next.
  3. 03Genome editing and CRISPR designModels that help researchers choose CRISPR guides, anticipate off-target risk and repair outcomes, and study AI-designed editors, checked against experimental data.
  4. 04Protein language models and designModels that learn structure and function from protein sequences, and generative methods that propose new candidates in silico.
  5. 05Single-cell and multi-omics modelsModels over gene expression measured cell by cell, for grouping cells by state, integrating datasets and estimating responses to perturbation.
  6. 06Research agentsAgents that read the literature, run dry-lab analysis and draft experiment plans, with a researcher deciding what happens next.

02Research focus

The open questions behind the work.

XS1 Biosciences is a research division first. These are the questions its work keeps returning to.

  1. How far does a sequence model generalize?

    Across species, genomes and assays that were not in its training data, and how to tell when it has stopped generalizing.

  2. Do zero-shot predictions track the bench?

    How closely variant-effect and fitness scores follow experimental measurements such as deep mutational scans.

  3. Can a model say how sure it is?

    Calibrated confidence for predicted structures and effects, so researchers know which predictions to trust and which to test.

  4. How should a research agent show its work?

    Every claim tied to a source, every analysis reproducible, every proposal ranked with the evidence behind it.

03Working with us

How work with XS1 Biosciences starts.

XS1 does not sell a packaged product. XS1 Biosciences takes on contracted research and engineering, and research partnerships, with research institutes, university labs and life-science R&D teams.

Contracted research

A defined question, such as adapting a sequence model to your assay data or testing how well models predict your measurements.

Contracted engineering

Training and fine-tuning pipelines, evaluation harnesses and research-agent tooling built around your dry-lab workflow.

Research partnerships

Longer-term collaboration on an open problem in AI for biology.

Every engagement starts the same way

  1. 1

    An initial conversation

    You describe the research question in general terms. No data or sequences are needed at this stage.

  2. 2

    Scope and responsible-science review

    We agree what the work will and will not do, and review the use case against our responsible-science practice.

  3. 3

    Terms agreed privately

    Data handling, access and publication terms are settled before any data changes hands.

  4. 4

    Work in reviewed stages

    Results are reviewed with your team at each stage. Your researchers decide what is tested in the lab.

What we do not take on

Work aimed at creating or enhancing biological threats, or any project that does not pass a responsible-science review.

Research use only: outputs support research and are not intended for decisions about individuals.

News

Latest from XS1 Biosciences

All XS1 Biosciences news
XS1 Biosciences

XS1 Biosciences adds genome editing as a research area

XS1 Biosciences has added genome editing (CRISPR) to its research areas, building models for guide RNA design, on- and off-target prediction, and editing-outcome prediction.

Research area
Genome editing (CRISPR)
Models for
  • Guide RNA design
  • On- and off-target prediction
  • Editing-outcome prediction

Work with XS1 Biosciences

Bring XS1 Biosciences a hard problem in biology.

Describe the research question in general terms. Qualified partners receive more detail after an initial conversation.

Work with XS1 BiosciencesContact

Please do not send unpublished data, sequences or other confidential material through this website.